Current Issue : October-December Volume : 2017 Issue Number : 4 Articles : 5 Articles
The objective of this study was to develop liposomes containing celecoxib in gel to enhance the dermal penetration using chondroitin sulfate. The liposomal gel was characterized by droplet size and zeta potential determination, entrapment efficiency, spreadability, in-vitro and ex-vivo drug release studies and drug content. The optimum formulation consisted of 300 mg phospholipon 90H and 12.5 mg cholesterol based on the statistical experimental design. Entrapment efficiency was in the range of 40-70% and drug release in the range of 75-87%. Animal studies of liposomal gel of celecoxib containing chondroitin sulfate showed 80% inhibition as compared to simple celecoxib gel and gel containing chondroitin sulphate. Therefore, liposomes containing celecoxib in the gel were successfully prepared using chondroitin sulphate as a penetration enhancer and thus dose of celecoxib can be reduced....
The objective of present study was to develop domperidone hydrogel beads for the effective management of emesis as gastro retensive drug delivery. The domperidone beads were prepared by ionotropic gelation methods using sodium alginate, hydroxyl propyl methyl cellolose, carboxy methylcellulose and sodium carboxy methylcellulose in various ratios. The result of FTIR spectra indicated that stability and compatibility of the drug with the polymer used. The formulated hydrogel beads were discrete, spherical with relatively smooth surface and with good flow properties. All prepared hydrogel beads were evaluated for drug entrapment efficiency, percentage yield, in-vitro swelling and in-vitro release study. SCMC loaded hydrogel beads shows the best batch (F5) was 84.96% in 12 hr respectively showing a better controlled release of drug....
The aim of the present study was to formulate and optimize moxifloxacin in-situ gels for the treatment of conjunctivitis. Moxifloxacin ophthalmic solution has been shown to be effective in ocular infections and may be used in patients with chronic conjunctivitis or ocular irritation. Moxifloxacin in-situ gel was prepared using various concentrations of polymers, such as carbopol-940 (0.1, 0.2, 0.3 0.4 and 0.5% w/v), HPMC-E50LV (1.5% w/v), HPMC E4M (0.6% w/v) and HPMC K4M (0.5% w/v), as a pH triggered gelling system, with the objectives of increasing contact time, achieving controlled release, reducing the frequency of administration and obtaining greater therapeutic efficacy of the drug. The prepared in-situ gels were then evaluated for their visual appearance, clarity, pH, drug content, in-situ gelation. Also, rheological studies, sterility testing, texture analysis and in-vitro drug release studies were carried out. It was evident from these studies that the polymeric in-situ gels formed were transparent and clear and possessed a satisfactory gelling capacity. The drug contents of all optimized formulations were found to range between 98.30-99.97%. The formulations of our in-situ gels possibly possessed characteristics of a pseudoplastic behavior. The developed formulations were light yellow in colour, therapeutically efficacious, stable, non-irritant and provided sustained release of the drug up to eight hours’ time....
The aim of this work was to formulate and evaluate the sumatriptan succinate fast dissolving buccal films used for the treatment of migraine. The design of developing fast dissolving drug delivery systems is to provide patient with more convenient means of drug administration and maximum drug dissolution in oral cavity and to bypass the first metabolism, to increase the convenience and compliance by the pediatric and geriatric patients. In the present investigation, HPMC was used as film forming agent, sodium starch glycolate was used as super disintegrant. Polyethylene glycol was used as plasticizer. Solvent evaporation method was used for the preparation of fast dissolving buccal films. The films were prepared and evaluated for film thickness, folding endurance, dispersion test, drug content and dissolution. Among all the formulations, formulation F1 released the drug up to 98% from the film within 35 seconds of time which exhibits faster absorption and also shows desirable characteristics of the film....
Iontophoresis is a non invasive permeation enhancement technique designed to improve the delivery rate of compounds across biological membranes. The technique generates an electrical potential gradient that facilitates the movement of solute ions across the membrane. Iontophoresis has been used greatest success in therapy of hyperhidrosis. Because of their charged nature and relatively large molecular size, iontophoresis may provide means for their effective delivery. This review discusses the advantages of iontophoresis which makes it suitable for transdermal delivery of drugs. The review also describe the basic mechanisms, various pathways etc for the successive and effective delivery of drugs across the skin with greater bioavailability. The Review gives tabular description of various iontophoretic research....
Loading....